Overview
Zollinger-Ellison syndrome is a rare condition wherein the stomach produces an excessive amount of gastric acid resulting in the ulceration of the tissues surrounding the stomach, small intestines and esophagus.
In extreme cases it may also result in the spread of gastrinomas - a gastrin secreting tumor that invade the pancreas and the upper part of the small intestines.
Epidemiology
The disorder may occur in early childhood. However, it is seen more often in patients between 20 and 50 years of age. Almost 2/3 of the tumors are likely to develop into cancer. Some person are more susceptible to the the tumor that cause the disease while in some places occurring at irregular intervals for unknown reasons.
Twenty five percent of ZES patient have a genetic syndrome known as multiple endocrine neoplasia type 1 or (MEN-1). Prognosis of the disease is related to tumor sizes and distance of the spread of the tumor or Metastasis. If left untreated it may develop into a malignant tumor.
This syndrome was first described in 1955 by Dr. Robert Zollinger and Dr. Edwin Ellison, surgeons at Ohio State University.
What are the signs and symptoms?
The symptom is associated with a feeling of a burning sensation and hunger in the upper trunk of the abdomen. It would take up to one to three hours after meals especially felt in the middle of the night. Compare to peptic ulcer the symptoms associated with Zollinger-Ellison syndrome are generally more painful and less responsive to treatment. The symptoms were the following;
Treatment and Laboratory Aid to Diagnosis
The drugs of choice
• Apo-Cimetidine
• Acid Reducer 200
• Acid Reducer Cimetidine
• Alti-Ranitidine
• Apo-Ranitidine
• Aciphex
• Acimax
• Enlon
• Famotidine-histamine receptorantagonist
• Heartburn 200
• Heartburn Relief 200
• Klasec
• Lanzoprazole-proton inhibitor
• Losec
• Maxor
• Novo-Cimetine
• Nu-Cimet
• Novo-Ranidine
• Nu-Ranit
• Omeprazole-proton inhibitor
• Prilosec
• Pantoprazole
• Peptol
• Protonix
• Panto IV
• Pantoloc
• Pantozol
• Pariet
• Probitor
• Ranitidine-histamine antagonist receptor
• Risek
• Rebeprazole
• Rabeprazole
• Somac Tagamet
• Tagamet HB 200
• Zantac
• Zantac-C
• Zantac 75
• Zantac 75 EFFERdose
• Zurcal
• Zoton
Nursing care:
Prevention
References:
1. Zollinger RM, Ellison EH (1955). "Primary peptic ulcerations of the jejunum associated with islet cell tumors of the pancreas". Ann. Surg. 142 (4): 709–23; discussion, 724–8. doi:10.1097/00000658-195510000-00015. PMID 13259432.
2. Mamura M, Komoto I, Ota S. Changing Treatment Strategy for Gastrinoma in Patients with Zollinger-EllisonSyndrome. World J Surg. Dec 13 2005;[Medline].
3. Jensen RT (2004). "Gastrinomas: advances in diagnosis and management". Neuroendocrinology 80 Suppl 1: 23–7. doi:10.1159/000080736. PMID 15477712.
Additional resources:
An in-depth informative post on this rare stomach disorder.
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